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JAMA. 1890;XV(9):324-326. doi:10.1001/jama.1890.02410350020002.
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Intestinal Antisepsis.  —( Wiener medizin. Presse, May 25, 1890.) To render innocuous the pathogenic organisms of the intestines, attempts have been made with drugs administered by the mouth or rectum. By the first method only those remedies are indicated that will pass through the stomach unchanged. Calomel is an agent of this class, but while serviceable in simple fermentative conditions, it is impracticable in infection of long duration. Bouchard used large quantities (100 grams daily) of pulverized carbon in typhoid fever; naphthalin, iodoform and salicylate of bismuth have also been recommended. These agents possess a certain antiseptic influence on the contents of the alimentary canal, but on the intestinal wall their action is nil, which fact receives confirmation in the treatment of typhoid fever. The intestinal antiseptics require heroic administration, and aside from toxicity, they are absorbed in the stomach and altered in their chemical constitution before attaining the desired


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