JAMA. 1907;XLVIII(22):1863-1864. doi:10.1001/jama.1907.25220480041004.
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The literature on the subject of extragenital chancres is so extensive that one naturally hesitates before adding to the enormous number of cases already recorded. The fact that the profession at large does not, as yet, seem to appreciate the frequency of this clinical occurrence I believe to be sufficient reason to warrant a brief report of six cases of primary syphilitic lesion of the lip.

All the patients are women. The first three were seen in private practice during the past year and a half, and the other three at the Presbyterian Hospital Dispensary within the past five months. Cases 3, 4 and 5 were presented at recent meetings of the Society of Dermatology and Genito-Urinary Surgery.

Case 1.  —A widow, aged 44.

Examination.  —When first seen at her residence, she was suffering from severe frontal headaches, and complained of the annoyance and disfigurement caused by an obstinate sore


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