In a previous communication1 I have shown how the natural defenses of the animals employed in the experiments were lowered or suspended when subjected to thorough narcotization. In the several series of experiments it was noted that the narcotized animals reacted, poorly to various infections artificially produced. It was also shown that the recovery or death of the rabbits depended apparently on the condition of the leucocytes. Narcotized rabbits when infected showed a hypoleucocytosis of various degrees, whereas the controls usually showed a pronounced leucocytosis which was followed by complete recovery or at least survival of their narcotized fellows by a considerable space of time.
These phenomena suggested the possibility that the narcotics had a deterimental influence on the phagocytic function of the leucocytes. It was also shown that there is a more active intraperitoneal phagocytosis of carmine granules in normal than in narcotized animals.
It was now thought