JAMA. 1907;XLVIII(15):1226-1230. doi:10.1001/jama.1907.25220410002001a.
Text Size: A A A
Published online


HISTORICAL NOTE.  In 1873, in a paper entitled "A Cretinoid State Supervening in Adult Life in Women," Sir William Gull1 first described the disease known later as myxedema. This name was suggested by Ord,2 in 1877, as he said, "To be applied to an essential condition in the cretinoid affection occasionally observed in middle-aged women." He also wrote:The whole collection of symptoms are related as effects to jelly-like swellings of the connective tissue, chiefly, if not entirely, consisting in an overgrowth of the mucous-yielding cement by which the fibrils of the white element are held together. Accordingly, I propose to give the name of "myxedema" to the affection.He further emphasized the similarity of myxedema and cretinism and among other things pointed out that in one of his cases (as in one of the cretins reported by Curling), there was diminution in size and almost complete


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.