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ARTICLE |

THE RELATION OF CHOLELITHIASIS TO DISEASE OF THE PANCREAS.

EUGENE L. OPIE, M.D.
JAMA. 1904;XLIII(16):1102-1105. doi:10.1001/jama.1904.92500160001a.
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The intimate relation of pancreatic disease to lesions of the liver is forecast in the embryo at a time when that part of the pancreas which will subsequently contain the larger pancreatic duct makes its appearance as two diverticula situated beside the embryonic hepatic duct where it enters the intestine. One of these rudimentary structures disappearing, the duct of Wirsung, which will subsequently become the outlet for almost the entire pancreatic secretion, enters the intestine in conjunction with the common bile duct. The smaller duct of the pancreas, the duct of Santorini has its origin in an embryonic diverticulum situated nearer the stomach. The two parts of the gland subsequently unite to form the adult organ, but the two ducts are subject to considerable variation, differing in their relation to one another and to the common bile duct.

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