JAMA. 1907;XLVIII(12):1032-1033. doi:10.1001/jama.1907.02520380048004.
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Until recently our knowledge of the character of the chemical reaction of the blood was very imperfect and inexact, and at present the more precise information which has been obtained through physicochemical studies seems to be possessed by few except those engaged particularly in physiologic research and teaching. The ideas of too many physicians regarding this vital question are limited largely to reminiscences of statements in the older text-books of physiology, to the effect that the blood is "amphoteric" in reaction, because with some indicators it reacts as if alkaline, whereas with others it reacts as if very faintly acid. It is not unusual to see statements in current literature to the effect that in certain diseases the alkalinity of the blood has been found to be reduced, and that it is important for the maintenance of resistance to infection that the alkalinity of the blood be kept at a


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