JAMA. 1907;XLVIII(12):1019-1021. doi:10.1001/jama.1907.25220380035001i.
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Relatively few well-described instances of simple ulcer of the bladder have been recorded, but these are sufficient to establish the existence of such a condition.

It may be defined as a single non-inflammatory ulcer located in the mucous membrane of the bladder, which occasionally penetrates the entire wall.

The condition is probably caused by a local disturbance in, or complete blocking of, the terminal arteries or by an interference with the trophic nerves. Infection of the bladder never produces it. It resembles in appearance a gastric ulcer and probably has a somewhat similar etiology.

I have observed two cases, the histories of which are as follows:

Case 1.  —A man, aged 54, previous health excellent; had a mild attack of gonorrhea 8 years ago, no complications.

Present Illness.  —For eight months he has suffered from a slightly increased frequency of micturition, attended by burning and discomfort. Very frequently during the


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