Relatively few well-described instances of simple ulcer of the bladder have been recorded, but these are sufficient to establish the existence of such a condition.
It may be defined as a single non-inflammatory ulcer located in the mucous membrane of the bladder, which occasionally penetrates the entire wall.
The condition is probably caused by a local disturbance in, or complete blocking of, the terminal arteries or by an interference with the trophic nerves. Infection of the bladder never produces it. It resembles in appearance a gastric ulcer and probably has a somewhat similar etiology.
I have observed two cases, the histories of which are as follows:
—A man, aged 54, previous health excellent; had a mild attack of gonorrhea 8 years ago, no complications.
—For eight months he has suffered from a slightly increased frequency of micturition, attended by burning and discomfort. Very frequently during the