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THE SIGNIFICANCE OF DECREASED HYDROCHLORIC ACID IN GASTRIC CANCER.

JAMA. 1907;XLVIII(9):798. doi:10.1001/jama.1907.02520350056004.
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Few facts in clinical chemistry have been more utilized and relied on in diagnosis than the decrease in acidity of the gastric juice in cancer of the stomach. The explanation of this fact has not been so satisfactory, however, for the degree of reduction in acidity has not been found to bear any constant ratio either to the extent of the growth or to its point of origin in the stomach. The coincidence of the location of the growth in the stomach with a decrease in the functional activity of that organ has naturally led to an association of the two facts, and emphasized the view that the decrease in acidity of the gastric juice in cancer of the stomach depends on some local effect of the tumor. This explanation, however, has never been satisfactory, for frequently a very local growth has been found associated with total absence of free

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