JAMA. 1904;XLIII(12):815. doi:10.1001/jama.1904.02500120051006.
Text Size: A A A
Published online

Hemophilia is a familial blood disorder transmitted principally through females, who themselves generally escape. The first manifestations usually appear in childhood, and the affection is rare after adolescence. Death is the usual outcome. An attempt has been made to distinguish a spontaneous and a traumatic form of the disease, but it seems probable that traumatism occurs in all cases, perhaps slight and unobserved at times. Gangrene is a not uncommon complication, being attributable to the pressure exerted by extravasations of blood on the surrounding tissues. Hemorrhage sometimes takes place into a joint, and the blood may be absorbed or a panarthritis may result, with deformity and ankylosis.

The etiology of hemophilia is obscure. The hemorrhage has been referred by some to a disproportion between the relatively large amount of blood and the capacity of the vessels; by others to their small caliber and the delicacy of their walls and to


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.