In a recent study in which one of us has been engaged, on the cardiac and vascular complications and sequels of typhoid fever,1 several rather suggestive facts have come to light with regard to the possible causal relation of this disease to sclerotic changes in the arteries.
One hundred and eighty-nine individuals who had passed through typhoid fever under our observation were examined months and years after their infection. It was found that among these individuals:
(a) The radial arteries were palpable in a surprisingly large proportion of cases as compared with control observations on healthy men and women who had never had typhoid fever.
Between the ages of 10 and 50, 48.3 per cent. of the old typhoids showed palpable radials, as compared with 17.5 per cent. among ordinary healthy individuals. These proportions held in every decade, and were not essentially modified in tables from which all giving a history of serious infections or alcoholic habits had been excluded.