The view that regards acute rheumatism as an infectious disease has now gained such general acceptance and has so completely superseded the older "chemical" and "neurotrophic" theories as to its nature that time need not be taken to review the facts which have led to such a general belief.
With the growth of this idea of the infectious nature of the disease it was but natural that a search for the infectious agent should begin and but natural also, considering the importance of the disease, that the search should be both eager and persistent.
To trace in detail the history of this search for the microbic cause would take us far beyond the scope of this brief paper. A great amount of work on this subject has been done during the past ten years and we can hope only to review briefly the results of this work.
As was perhaps