JAMA. 1907;XLVIII(1):56. doi:10.1001/jama.1907.02520270062011.
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The work of a quarter of a century ago on the lodgment of emboli would have led one to expect that bone metastases should be common in any form of tumor whose cells escaped into the blood current. Experience has shown that something more than a mechanical factor is at work in these cases, and that the types of tumor which give rise to bone metastases are not very frequent. The not infrequent bone metastases with tumors of the breast, prostate, stomach and thyroid are well recognized, but it is only of late that we are beginning to realize that hypernephromata frequently cause secondary growths in the bones. Scudder's1 recent study brings out some interesting facts. The most important one refers to the frequency with which these peculiar tumors are latent. Here, as is often the case with the metastasizing thyroid tumors, the original growth may remain so small


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