Relative to the case reported by F. C. Bennett in The Journal A. M. A., November 17, I recently had an experience with adrin. The patient was given tablets containing among other medicants adrin gr. 1/500, with directions to let one dissolve slowly in the mouth every three or four hours. The patient used one every hour for six doses, and then telephoned that he was suffering greatly with his heart and that pulse was "very rapid and weak, with smothering." I at once ordered recumbent position and strong black coffee, with almost immediate relief. I have used adrenalin and adrin a great deal with cocain, and have witnessed these phenomena before, but heretofore have attributed it to cocain, but there was no cocain in these tablets.