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JAMA. 1906;XLVII(25):2095-2096. doi:10.1001/jama.1906.02520250049006.
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Careful anatomic investigation would often make clear the mode of origin of many an obscure infection. In the presence of inflammatory intracranial disease attention is quite commonly given to the ear as the possible primary focus, and, while it is realized that infection of the cranial cavity may take place by way of the nose, the frequency of this mode of invasion is perhaps not generally appreciated. As a matter of fact, collections of pus in the various accessory nasal sinuses are not uncommon, especially in association with inflammatory affections of the cranial cavity. Of the sinuses the maxillary is the one most frequently involved, the sphenoidal being next in frequency. Attention is called to the importance of this subject by Dr. St. Clair Thomson,1 who reports a case of acute suppurative basic meningitis and one of thrombophlebitis of the cavernous sinus secondary to purulent inflammation of the sphenoidal


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