JAMA. 1906;XLVII(21):1719-1722. doi:10.1001/jama.1906.25210210027001g.
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The recent consolidation of the different forms of mania and of melancholia into the one disease called manic-depressive insanity is a notable achievement and at the same time furnishes one of the most important of the recent problems of psychiatry. The fusion of so widely differing symptom complexes into one type, and their presentation as a definite disease can only be justified by showing that the same pathologic process or, what is quite different, that the same cause underlies the manifestations in all cases. It is important to investigate and group the cases of so common a difficulty as the so-called manic depressive type, to find out whether the diagnostic criteria are justified, whether the prognosis is hopeless, as to permanent cure, as is implied in the definition ordinarily given of the disease and the treatment restricted to care and palliation, or whether some cases of the disease being curable,


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