JAMA. 1896;XXVI(23):1108-1112. doi:10.1001/jama.1896.02430750010001d.
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I need offer no apology for the introduction of a subject such as this, as it is well deserving of our attention by virtue of its high degree of importance in diagnosis and treatment. The frequency of syphilis of the nervous system is becoming more and more appreciated, thus securing for it an earlier recognition and the establishment of a more definite train of clinical phenomena than formerly. Gray, writing only four years ago, would make no more than a tentative diagnosis of cerebral syphilis, unless there were present, 1, undoubted specific infection; 2, convulsions or hemiplegia, or 3, marked success of specific treatment. Gowers, in his great work, allots to nervous syphilis no special chapter, referring to it among causative agents in the production of endarteritis, cerebral softening, hemorrhage, insanity, etc. I need not dwell upon the widespread prevalence of syphilis, which is one of the most important diseases


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