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ARTICLE |

THE VARIABILITY OF SUPRARENAL PREPARATIONS.

JAMA. 1906;XLVII(10):783. doi:10.1001/jama.1906.02520100055012.
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ABSTRACT

The contribution by Dr. Reid Hunt and the reports of Drs. Sollmann and Brown, appearing in our Pharmacology department this week, represent entirely independent investigations, executed on different animals and by somewhat different methods. They are, however, in striking agreement by showing that the various solutions of suprarenal alkaloids on the market are far from uniform. Hunt's examination demonstrated that to produce equal effects it required of one brand five times as much as of another. Specimens obtained from one manufacturer were of uniformly good quality; one specimen obtained from another manufacturer was good, another from the same firm was inferior, while the products of one of the firms, obtained directly from the company, were uniformly bad. The report of Sollmann and Brownshows that the activity varies commonly from 65 to 100, and one sample was inactive. As pointed out by Sollmann and Brown, these results have a purely negative

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