JAMA. 1906;XLVII(10):739-741. doi:10.1001/jama.1906.25210100011002b.
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In the treatment of tuberculosis we have to deal with tubercle bacilli, on the one hand, and the human being on the other. The quantity of powerful drugs daily taken by those unfortunates who have acquired the drug habit demonstrates the power of the human organism to accommodate itself gradually to changed conditions. It appears reasonable to suppose that if powerful poisons, such as chloral, cocain, arsenic, morphin, etc., can be tolerated by the human subject in gigantic quantities, then a like tolerance can be created for certain other drugs of less toxic influence, but possessed of bactericidal properties.

Through a tolerance thus acquired it may be possible to administer such germicidal substances in quantities sufficient to inhibit, damage, or even destroy pathogenic bacteria, such as tubercle bacilli, within the body, and to do this without injury to the human body. This hypothesis presupposes the lack of a similar or


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