This case is reported because it is interesting and encouraging, in view of the slight tendency to spontaneous improvement in cretinism.
—A girl, aged 12.
—The father had chronic nephritis, in an advanced stage, when the child was born. On the maternal side the history is negative. There is no history of cretinism or mental defect. The patient is the youngest of four children. The sister has never been strong, but gives no history of organic lesions. One brother has asthma; a second brother is excessively nervous. Nine years elapsed between the birth of the second brother and the patient.
—As an infant, the patient slept much and cried little. The first teeth were not markedly late in appearing, but were very irregular. The child walked at two and one-half years. The hair was stiff and straight. The skin easily roughened, with a tendency to