The following case, seen in consultation with Dr. Alexander C. Wiener, is reported not as such an extraordinary case, for it is one of amyotrophic lateral sclerosis, but on account of the association with it of inequality of the pupils. This association is exceptional. Case 1.—Mrs. J. P., aged 49, twice married, has two healthy children by her first husband. During the nine years of married life with her second husband she has borne no children, but has had four or five early abortions.
—Her father died of consumption when the patient was six years old. Her mother died of paralysis of the heart at the age of 56. She has a half brother and a sister in perfect health. Nothing further of interest is in the family history. She had the usual children's diseases, and a severe attack of inflammation of the bowels twelve years ago. Menstrual