JAMA. 1906;XLVI(20):1523-1526. doi:10.1001/jama.1906.62510470037002.
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DRUGS ACTING ON THE SKIN AND MUCOUS MEMBRANE, MAINLY WITH REFERENCE TO EXTERNAL USE.  There are so many substances which have been used as irritants under varying conditions that we can not attempt to do more than mention the more useful of the agents frequently employed for this purpose, together with some of the conditions in which clinical experience has shown them to be most beneficial.While the employment of counter-irritants is almost wholly empirical, the regions of the skin which Brunton has indicated for their use when it is desired to influence the internal organs correspond well with those which Head has shown to exhibit tenderness of the skin in connection with diseases of the same organs.Brunton directs the irritant to be placed over the larynx, ovaries or sciatic nerve for affections of those parts, over the ensiform cartilage for gastric disturbance, above and below the


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