JAMA. 1903;XLI(24):1480-1481. doi:10.1001/jama.1903.02490430034008.
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When Pawlow demonstrated that pancreatic juice as secreted into the intestine in an inactive form is rendered active by another ferment, enterokinase, secreted by the intestinal mucosa, he did more than give a new light on the processes of digestion in the intestine, important as that contribution was. He also pointed the way to new researches that might show other examples of the interdependence of organs and cells. One of the fruits of this research seems to have matured in the very important discovery of O. Cohnheim1 concerning the mechanism and the agents concerned in sugar metabolism, apparently a discovery that clears up at last one of the most fundamental processes of metabolism which has evaded solution in spite of much work directed to that end. It is indeed strange that the history of sugar in the body has not been completely worked out long ago, in view of


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