JAMA. 1914;LXII(8):583-589. doi:10.1001/jama.1914.02560330001001.
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Doerr1 of Vienna closes an excellent review of recent work on so-called anaphylaxis or protein sensitization with the following paragraph:

While it must be admitted that the action of those infective bacteria which are not known to produce specific toxins remains without explanation, and while the theories which have been developed by von Pirquet, Friedberger, Vaughan, Schittenhelm, Weichardt and others have opened up a new way to the understanding of incubation, fever and crises, still it must be borne in mind that the premises of these theories do not possess the force of demonstrated facts. It has not been positively shown that the symptoms of anaphylaxis are due to the parenteral cleavage of proteins, that the true anaphylactic poison is identical with that produced in vitro and that both come from the antigen. Even if we agree with Dold, Sachs and Ritz that so far as the rôle of


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