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JAMA. 1896;XXVII(20):1042-1043. doi:10.1001/jama.1896.02430980014001g.
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My experience with pyoktanin probably differs little from that of your own in those suppurative troubles of the eye and ear for which it has been considerably lauded, i.e., occasionally very satisfactory, but more often disappointing, if not indeed aggravating. In fact after many disappointments I practically discarded it from my list of remedies as I have no doubt many have done.

About two years ago, however, after an unsuccessful attempt to treat a case that I had diagnosed as phlyctenular conjunctivitis, by the classical method, viz.: Pagenstecher's ointment, calomel dust and mydriatics locally, plus alterative and tonic medication internally, pyoktanin in 1-1000 aqueous solution locally was accidentally suggested. To my surprise the case improved rapidly under it and was soon well. A month later the patient, an anemic girl of 15 years, returned with a fresh efflorescence. Again was the Pagenstecher's ointment and calomel dust distinctly irritating and the


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