The observations recorded in this paper were made on the parasites obtained in the tissue and by artificial culture from the case of fatal systemic blastomycosis reported by Ormsby and Miller.1 We wish here to acknowledge their assistance in the work done and kindness in allowing us to use the material from their case.
In May, 1894, Gilchrist2 described in tissues from a skin lesion the spherical, double-contoured, budding microörganisms which have since been observed in about thirty-five reported cases. In this case cultures were not made and little was known of the biology or nature of the parasite. In November of the same year Busse3 reported a case of systemic infection resulting fatally in which a similar parasite was described as the etiologic factor. Cultures were made from this case and the organisms extensively studied by Buschke.4 In culture the organism grew by budding, and mycelial