This second edition has been brought fairly well up to date by the inclusion of some of the newer and better diagnostic methods. Thus, among other insertions, are found the antiformin method for tubercle bacilli, the formalin test for ammonia in urine, Benedict's test for sugar in the urine, Wright and Kinnicutt's method of counting the blood-plates, and a satisfactory, though brief, discussion of the Wassermann reaction. While these important additions have increased the value of the work, certain omissions have been noted, which should not have occurred. Thus, no mention is made of the phenolsulphonephthalein test for the functional activity of the kidney, the best of all tests for this purpose. Further, Todd advises the quantitative estimation of the chlorids, phosphates and sulphates of the urine by centrifugal methods. These are very inaccurate and have no value in the only place in which such determinations have a place, namely,