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NOTES ON SPERMINE.Read at the Chicago Medical Society, Sept. 17, 1894.

JAMA. 1894;XXIII(18):676-684. doi:10.1001/jama.1894.02421230016001d.
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Last April I had occasion to exhibit before you a patient previously suffering from a severe form of chorea, who recovered completely and permanently after six injections of spermine. Since then I have had an opportunity to see the efficacy of this treatment in a similar case still more pronounced than in the one exhibited.

The patient who now stands before you is a boy, 6 years of age, who has since the last two years been suffering from chorea. During this time he was under treatment of several physicians who applied the common remedies and electricity without success. Last May the boy was brought to Dr. Bettmann for examination of his eyes. Dr. Bettmann, who will report more definitely, prescribed suitable glasses. Two months later the Doctor referred the case to me for a treatment with spermine injections.

When I first saw the boy, his fingers and muscles of


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