JAMA. 1894;XXIII(17):646-647. doi:10.1001/jama.1894.02421220018001i.
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This troublesome spasmodic condition, whether we term it a disease, or only a symptom, may well be classed as one of the opprobria medicorum; presenting as it does in its clinical history the appearance of a spasmodic disease, and in its therapeutics almost negative results as regards the action of antispasmodics and nerve sedatives, the practitioner may well inquire after a new explanation of its pathology and a new departure in its treatment. Most practitioners of large experience have doubtless met with cases in which this singularly annoying and debilitating condition has continued for many days, even running into weeks, in spite of their best therapeutic efforts, with scarcely any intermissions, unless asleep, and which sleep came but seldom and was transient. Any new remedy or any old remedy whose successful application to the treatment of this condition is new, deserves the attention of the profession.

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