JAMA. 1911;LVII(21):1698-1701. doi:10.1001/jama.1911.04260110198020.
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THE CULTIVATION OF THE SPIROCHÆTA PALLIDA  During the past decade remarkable advances have been made in the placing of the pathology of syphilis on a sound basis. In 1903, Metchnikoff and Roux first demonstrated the experimental production of the disease by animal inoculation; two years later Schaudinn and Hoffmann announced the discovery of the Spirochœta pallida, since conceded to be the etiologic agent of the disease; and in 1906 Wassermann, Neisser and Bruck published the method of serum diagnosis with which we associate their names.Schaudinn and Hoffmann gave excellent descriptions of the morphology of the Spirochœta pallida and detailed methods of demonstrating the organism in the secretions and in the tissues of syphilitic lesions. Many observers confirmed their observations, but,


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