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THE DISADVANTAGES INCIDENT TO THE ADMADMINISTRATION OF SALVARSAN

DOUGLASS W. ONTGOMERY, M.M.D.
JAMA. 1911;LVII(21):1661-1666. doi:10.1001/jama.1911.04260110161004.
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Salvarsan in its present form can never become a popular remedy. Paul Ehrlich, however, is so ingenious that any day he may invent a modification that will be more easily administered, and will be even less toxic.

There are three determinations of salvarsan that are of fundamental imptance; its poisonous action on the Spirochœta pallida; its selective action on epithelial tisue; and its selective action on the tissue of nerves. Its stimulating action on epithelial tissue is shown in the marvelous way mucous patches and leutic ulcers epidermize under its influence. Its selective action on nerve tissue, however, is what immediately interests us in this paper.

On the introduction of salvarsan, the attention of observers was fixed on the optic nerve, as it was feared that salvarsan might, like atoxyl, cause amaurosis. But experience accumulated, and as no reports of dissagreable ocular symptomss were at first recorded it wass hoped

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