Chicago, Nov. 7, 1907.
To the Editor:
—In The Journal, Oct. 5, 1907, is an article by Dr. Miles and an editorial on the above subject. The suggestion is made in these articles that the various experimental vascular changes that have been produced during the past four years may be in reality of spontaneous origin. Jores' exhaustive dissertations on arteriosclerosis which appeared just previous to Josué's successful experimental work, reviews the various attempts to produce arterial changes in animals and especially in rabbits, and the total number of animals carefully examined must have been large and yet in not one of these were they able to detect vascular changes. In 1900 Crofton reported atheroma in two rabbits as a result of injections with hypoxanthin. Fisher, while working with adrenalin arteriosclerosis, reports that in some poorly nourished animals he found slight spontaneous changes resembling those produced by adrenalin. Ophüls, also, recently