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THE PRODUCTION OF IMMUNITY IN TUBERCULOSIS BY INTRAVENOUS INJECTIONS OF TUBERCULIN

C. A. SHEPARD, M.D.
JAMA. 1911;LVII(12):945-950. doi:10.1001/jama.1911.04260090167003.
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In the treatment of no other disease have there been such strides made in the past few years as in that of tuberculosis. From time immemorial this disease has attracted the best attention of the medical profession, and various have been the remedies and measures proposed for the alleviation and cure of the great white plague, which at the present time is depopulating this good old world of ours at the rate of 1,000,000 a year, and causing a loss to the nation of many millions in money.

Immunity against any disease is based on the fact that the body in the presence of infection and its products has the power to elaborate specific substances—an tibodies—that neutralize the toxic microbic product, and promote the destruction of the infectious organisms. We are all familiar with the natural immunity produced after certain diseases, such as small-pox, scarlet fever, yellow fever, cholera, and

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