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EXPERIMENTS ON THE TRANSMISSION OF SCARLET FEVER TO MONKEYS

LUDVIG HEKTOEN, M.D.; GEORGE H. WEAVER, M.D.
JAMA. 1911;LVI(24):1795. doi:10.1001/jama.1911.02560240025010.
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ABSTRACT

In view of recent reports of the successful inoculation of monkeys with scarlet fever it was thought of interest to relate some experiments made in the interval from Dec. 10, 1909, to September, 1910. Materials from the throats and mouths of children with scarlet fever were collected on cotton swabs and the swabs washed off in milk. The milk thus infected was fed to monkeys. Thirteen monkeys (Macacus rhesus) were fed in this way; ten remained well, showing no fever or leukocytosis, and three died. The three monkeys which died may be designated as Nos. 1, 2 and 3.

No. 1 was fed the infected milk on Dec. 10, 11, 13 and 14, 1909, became sick December 20, and died December 21. The autopsy showed a fibrinous peritonitis. The peritoneal exudate and the heart's blood contained colon bacilli; no streptococci or other bacilli could be demonstrated by microscopic or cultural

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