JAMA. 1915;LXV(2):166-169. doi:10.1001/jama.1915.25810020001015.
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THE HEAVY METALS AND THEIR SALTS  The salts of the heavy metals act locally as astringents, irritants or corrosives, dependent on the nature of the compounds which they form with the tissues; thus the lead salts, which are astringent when used in dilute solution, are corrosive when concentrated solutions are employed.The intestinal mucous membrane acquires a certain degree of tolerance toward irritant action of the metals if small doses are given at first, and gradually increasing amounts are employed. The large amounts of arsenic taken by the arsenic eaters of the Tyrol afford a well-known example of this acquired tolerance.The salts of metals which dissociate readily into their ions have many actions in common after the absorption of toxic doses into the circulation. The marked differences in the effects commonly observed after their administration are attributable in part to differences in their rates of absorption, in part


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