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JAMA. 1917;LXIX(22):1865-1873. doi:10.1001/jama.1917.02590490029006.
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Phlorizin is a glucosid which was discovered by de Koninck in 1855. It is derived from the root-barks of various fruit trees, which, when brought to boiling in acid mediums, give off a glucose called phlorose, and a glycogen, the so-called phloretin.1 Phlorizin occurs in minute and slightly pinkish crystals, and is sparingly soluble in cold water, alcohol and ether, but freely soluble in hot water from which solution it crystallizes out on cooling.2 In 1885, von Mehring3 found that phlorizin produces glycosuria in man. Ten years later the first statement in regard to the renal origin of phlorizin glycosuria was made by Zuntz,4 who, after introducing cannulas into the ureters of a dog, exposed one kidney, into the renal artery of which phlorizin was injected, with the result that sugar appeared first and in greater amount from the ureter of the injected kidney. That phlorizin


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