JAMA. 1907;XLIX(14):1158-1162. doi:10.1001/jama.1907.25320140004001a.
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The symptom-complex which we know under various names as exophthalmic goiter, Graves' disease, Basedow's disease, etc., has been very extensively studied, but even yet there is not perfect unanimity of opinion as to the anatomic changes which underlie these symptoms. Nearly all writers, except certain clinicians who have not made anatomic investigations, agree that there are always changes in the thyroid, although there has been much debate as to whether these changes are constant in character or not. There are others who think that the lesions must be sought in the sympathetic system or in the central nervous system, while still others regard the disease as the result of a functional disturbance of the nervous system and do not expect to find gross anatomic changes. Other attendant lesions in the eyes, in the skin, the muscles, the digestive tract and in the lymphoid tissue and thymus have been frequently described,


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