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JAMA. 1917;LXIX(18):1498-1500. doi:10.1001/jama.1917.02590450018006.
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Since the discovery by Magnus and Schaefer1 in 1901 of the diuretic action of extracts of the posterior lobe of the hypophysis, attention has been directed to that organ as an important factor in the causation of diabetes insipidus. Frank,2 in an important article published in 1912, reviewed the literature then existing on the subject and made a strong plea for a consideration of the relationship between the hypophysis and diabetes insipidus. Numerous writers already had emphasized the fact that lesions of the brain which involved the vicinity of the hypophysis were often accompanied by polyuria without sugar. Oppenheim,3 in thirty-six cases of basal syphilitic meningitis, observed polyuria in twelve. Two of these showed at necropsy a gumma of the optic chiasm and hypophysis. Kruse,3 in a study of thirty cases of bitemporal hemianopsia, observed diabetes insipidus in seven; and Spanbock and Steinhaus3 mention its


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