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JAMA. 1907;XLIX(8):680-681. doi:10.1001/jama.1907.25320080048001n.
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Coagulation necrosis is usually defined as that form of death of tissue in which the proteid suffers change similar to or identical with coagulation. It is known that this condition can be induced by various chemical substances, as acids, alkalies, and metallic salts; by some of the alkaloids; by vegetable poisons, as ricin and abrin; and by bacterial poisons. In addition to these causes it has been suggested that ferments derived from the body cells may, under certain conditions, produce similar effects as in the case of anemic infarcts of the spleen and kidney.

It seemed probable that additional information could be gained of the factors underlying coagulation necrosis by studying the factors underlying the coagulation of culture media, containing blood serum, through bacterial agencies, as well as by experiments upon animals.

A study of the factors underlying the coagulation of blood serum in the form of the well-known Hiss


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