TWO CASES OF BRAIN TUMOR WHERE OPTIC NEURITIS WAS THE ONLY POSITIVE SIGN—AUTOPSIES.Read before the Section on Ophthalmology at the Forty-fourth Annual Meeting of the American Medical Association.

JAMA. 1893;XXI(17):607-609. doi:10.1001/jama.1893.02420690015001e.
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Although pathognomonic symptom is a term in medicine, yet taken in its strict interpretation we have no symptom by which we can positively determine a disease without question. Taken in its better sense, a characteristic symptom of a disease, we may call optic neuritis a pathognomonic symptom of brain tumor. This has been so well established that it needs no discussion. The object of this report is not to further establish that fact, but to present two cases where optic neuritis was the first, and up to the time of its discovery, the only positive sign upon which a diagnosis could be based. For that reason I take it, brain tumor, with its ophthalmic aspects may be worthy of a discussion here, inasmuch as the ophthalmologist is sometimes called upon to give his opinion and to aid in the diagnosis of a case. To give positive or negative evidence as


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