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JAMA. 1917;LXVIII(18):1315-1317. doi:10.1001/jama.1917.04270050017007.
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History.  —A man, aged 28, complained of "stomach trouble," present periodically since boyhood, and progressively worse during the last few years. At first a hot drink gave relief. For the past year he had had sharp epigastric pain, irregular in onset, with no special relation to meals. If he retired early, however, the pain occasionally wakened him at midnight, that is, six hours after supper. If he was up late and ate on retiring, he usually slept until 3 or 4 a. m. Eating seemed to ward off the pain. He had had no nausea, vomiting, pain in the back, hematemesis or bloody stools. When in high school his weight was 182; it was now 158, of which he had lost from 10 to 15 pounds within the past year. Fifteen months before, the patient had been under the care of a physician who suspected ulcer, but on negative stools


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