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SOME FACTORS ALLEGED TO INFLUENCE THE DURATION AND SEVERITY OF VACCINIA

JOHN N. FORCE, M.D., Gr.P.H.; IDA M. STEVENS, M.A.(P.H.)
JAMA. 1917;LXVIII(17):1247-1250. doi:10.1001/jama.1917.04270040235011.
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This paper gives the results of some experiments undertaken to determine what influence would be produced on the duration and severity of vaccinia by the use of different preparations of vaccine, and various methods of treating the vaccinia vesicle.

TECHNIC OF VACCINATION AND COURSE OF RESULTING VACCINIA  In order to secure uniformity, the following technic, discussed at length in a former paper,1 was employed throughout this series:The arm in the region of the deltoid insertion was washed with alcohol and dried with sterile cotton. A small chisel provided with a carbon steel point was sterilized by dipping in alcohol and flaming. Three circular scarifications, each 2 mm. in diameter, were made through the epidermis by rotating the chisel edge against the tightly drawn skin. A sterile toothpick was used to transfer a drop of smallpox vaccine from its containing vial to the three scarifications, and to rub it

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