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OBSERVATIONS ON THE EXCRETION OF DYES

RUSSELL L. CECIL, M.D.; RICHARD WEIL, M.D.
JAMA. 1917;LXIX(7):521-523. doi:10.1001/jama.1917.02590340021006.
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ABSTRACT

The excretion of dyes offers a problem which is of interest from a variety of standpoints. It has a physiologic application on account of the light which it may throw on the functions of the excretory organs, and on the mechanism utilized by the body for the removal of waste material. Pharmacologically, it offers a simple method for the investigation of relationship between chemical structure and excretory function. Finally, it affords the clinician an instrument of precision in determining excretory activity. The method was introduced many years ago in the study of kidney function, and a variety of dyes have been employed for this purpose, of which the one in most general use today is phenolsulphonephthalein. An attempt has been made to study liver function in a similar manner, but the procedure has not proved entirely successful. The present paper reports on certain observations which throw new light on various

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