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THE TREATMENT OF INFECTED WAR WOUNDS

JAMA. 1917;LXIX(4):286-287. doi:10.1001/jama.1917.02590310038013.
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In a recent lecture,1 Sir Almroth Wright discusses at length the development of infection in wounds with special reference to treatment, particularly of wounds received in battle. He starts on the basis that the defense against infection of the body is due in part to the bactericidal action of the liquid of the blood, in part to phagocytosis by leukocytes. The bactericidal action of the blood fluid is dependent largely on its maintaining an antitryptic condition or property — if the serum of an exudate is not antitryptic it is not bactericidal. One of the ways in which the antitryptic quality may be reduced or lost is the death or breaking up of leukocytes so that their tryptic ferments are set free and neutralize antitryptic action. Under the natural conditions in a wound, and particularly a war wound, in which case there is much injury to tissue, and infectious

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