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January 20, 1917, Vol LXVIII, No. 3 >
ARTICLE | January 20, 1917

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1917;LXVIII(3):200-204. doi:10.1001/jama.1917.04270010200016.
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SATURDAY, JANUARY 20, 1917 

SOME EFFECTS OF EPINEPHRIN ON THE DISTRIBUTION OF THE BLOOD  Early in the investigation of the action of extracts of the suprarenal glands and the preeminently active component, epinephrin, produced by them, it became apparent that this substance can exert a pronounced local vasoconstriction. The contraction of arterioles which it brings about has rendered it one of the most powerful local styptics; in the same way not only hemorrhage but also inflammation is diminished in mucous membranes to which solutions of epinephrin are applied locally. The first classic researches on the effects of suprarenal extracts injected directly into the circulation showed as the invariable outcome a pronounced rise of blood pressure

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