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THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1917;LXVIII(1):36-39. doi:10.1001/jama.1917.04270010036012.
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SATURDAY, JANUARY 6, 1917  A STUDY OF CROSSED TOLERANCE FOR DRUGSThe expression "crossed tolerance" has been employed to designate the altered susceptibility which subjects that have acquired a considerable degree of tolerance for one drug or poison may thereafter exhibit toward another potent substance. In certain instances this phenomenon is well recognized. A habitual drunkard, tolerant to large doses of alcohol, usually is noticeably resistant to the general anesthetics. It is not difficult to understand the occurrence of crossed tolerance in the case of drugs very closely related which act in essentially similar ways on the organism; but as the mechanism of habituation and increased resistance to drugs is little understood in all but

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