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PRACTICAL PHARMACOLOGY

JAMA. 1915;LXIV(22):1846-1849. doi:10.1001/jama.1915.25710480001015.
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DIAPHORETICS  One of the functions of the sweat glands is to provide moisture, which by its evaporation cools the body, the secretion of sweat being increased when the production of heat by the body is increased.This secretion is controlled largely by the heat regulating centers, and when the blood flowing through the carotids is warmed it causes an increased secretion, as does the warming of the surface of the body also.The activity of the sweat glands is influenced less by the blood supply than is that of most of the glands of the body, and profuse sweating may occur when the skin is pale, and, on the other hand, there may be little secretion when the skin is flushed and hot in fever. However, heat increases the excitability of the nerve endings in the sweat glands and an abundant supply of blood often promotes the secretion.The

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