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THE COMPOSITION AND PHYSIOLOGIC ACTIVITY OF THE PINEAL GLAND

FREDERIC FENGER
JAMA. 1916;LXVII(25):1836-1838. doi:10.1001/jama.1916.02590250038014.
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Within the last few years the pineal gland has attracted some attention as a result of experiments conducted by Dana and Berkeley,1 and McCord.2 They fed this gland to young animals such as dogs, guinea-pigs, chicks, rabbits, cats, etc., and found that it caused them to outgrow the control animals, both in size and in sexual maturity. The addition of even small amounts of desiccated gland to the food is stated to be sufficient to produce marked results. It has also been found that infant glands are more active and give better results than adult glands. The present investigation was carried out for the purpose of determining the constituents and physiologic activity of this gland and to ascertain if any difference exists in glands from different species and between glands from young and from mature animals. Cattle, sheep and lambs, which usually furnish the raw material for pineal

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