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ACUTE LYMPHATIC LEUKEMIA

CHARLES E. SIMON, B.A., M.D.; CHARLES C. W. JUDD, B.A., M.D.
JAMA. 1915;LXIV(20):1630-1633. doi:10.1001/jama.1915.02570460006002.
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In 1910 Fraenkel and Much1 pointed out that peculiar granular bacilli may be demonstrated in the glands of patients in cases of Hodgkin's disease by "reinforced" gram-staining. These bacilli, which closely resemble the granular type of the tubercle bacillus, like them are resistant to antiformin (alkaline hypochlorite solution). Unlike the latter, however, they are not acidfast, and do not give rise to tuberculous lesions in laboratory animals. In their first communication the writers report on the presence of these organisms in twelve of thirteen cases, of which eleven were definitely known to be uncomplicated by tuberculosis. In a subsequent communication Fraenkel2 states that he obtained corresponding findings in four additional cases. He concludes that Hodgkin's disease (lymphomatosis granulomatosa) is in all probability an infectious disease produced by the micro-organism in question, which may be related to, but is not identical with, the tubercle bacillus. Regarding the morphology of

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