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H. N. COLE, M.D.
JAMA. 1916;LXVII(25):1805-1810. doi:10.1001/jama.1916.02590250007002.
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The extragenital chancre is by no means an uncommon sight — to the dermatologist, at any rate — and I feel a hesitancy in reporting to this section such a short series of cases. However, the affection is rather rarely encountered by the general practitioner and, consequently, the diagnosis is deferred, as a rule, until the appearance of the secondary symptoms, a time when much damage often has been done both to the patient and to his family.

DEFINITION  By the term "extragenital chancre" I mean the primary invasion of the Spirochaeta pallida on other parts of the body than the genitalia — hence the frequently used term "syphilis insontium." This type of syphilis has been known since the earliest times, and authentic epidemics of innocent syphilis have been reported as early as 1577 in Austria, 1592 in Switzerland and 1596 in Germany. Most of the earlier ones were due


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