Although a new chapter in the therapeutics of certain diseases of the skin has been opened by the use of human serum, so little has as yet been reported that all additional information is of the utmost value. The following case of obstinate urticaria associated with joint pains and a purpuric eruption presents some points of much interest. The disease did not yield to any of the ordinary methods of treatment, and it was found that the coagulation time of the blood was markedly increased. While some of the skin reactions with foreign proteins were somewhat suggestive, none was really positive, and the elimination from the diet of the substances which gave suggestive reactions had no apparent results. Epinephrin had a temporary beneficial effect.
On account of the increased coagulation time of the blood, and the fact that this time returned to normal when a drop of fresh human serum